Wnt signaling in hematopoietic stem cell development and cancer
The Grainger lab at San Diego State University is interested in the mechanisms that govern how stem cells are made, maintained and become cancerous. In particular, we are interested in the Wnt signaling pathway works in the development and homeostasis of blood stem cells. We use the zebrafish and cell culture as model systems.
Hematopoietic stem cells (green) amongst endothelial cells (magenta) in one of their developmental niches
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